Your Family History May Be Telling You Something.
A genetic risk factor called Lp(a) may explain why heart disease runs in families. See if the OCEAN(a)-PreEvent Study is right for you.
I’m Interested
A genetic risk factor called Lp(a) may explain why heart disease runs in families. See if the OCEAN(a)-PreEvent Study is right for you.
I’m Interested
Lipoproteins carry cholesterol throughout the body, but too much cholesterol can build up on the artery walls, causing blockages that can lead to cardiovascular events.
Most lipoprotein levels can be seen and managed through lipid panels (blood tests) at the doctor’s office. However, there is another type of lipoprotein called lipoprotein(a), or Lp(a), that is not included in standard lipid panels. Many people are not familiar with it.
Lp(a) has an additional “sticky” layer compared to other lipoproteins - that means it’s more likely to cling to the walls of the arteries and create blockages.
Having an elevated level of Lp(a) results in build up within the arteries that can increase the risk of heart attack and stroke.
You can have elevated Lp(a) even if you live a healthy lifestyle and manage other heart disease risks. The amount of Lp(a) you have is inherited, which means it is predetermined by your genes.
The LPA gene contains the instructions to create Lp(a) and if you inherit an elevated level, there is currently no approved medication or lifestyle changes that can change that.
Despite being a risk factor for increased risk of heart disease, Lp(a) is not measured as part of a standard lipid panel and typically must be ordered separately.
Knowing your Lp(a) level may help you make more informed decisions about your heart health.
Learn More
The OCEAN(a) - PreEvent study wants to understand whether a study drug may potentially impact the heart disease risk in adults with elevated Lp(a) levels prior to any heart-related event.
You may be eligible to participate in this study if you:
Are 50 years old and above
Have an elevated lipoprotein(a) (Lp[a]) level
If you don’t know your Lp(a) level, that’s okay. The study team will run an Lp(a) test as part of screening if you’re eligible to move forward.
Have history of blockages in arteries without an artery-related event (ex: heart attack, stroke) or are considered at risk of developing heart disease
Other eligibility criteria apply and will be evaluated by a study doctor.
Check Your Eligibility
Currently, 1 in 5 adults worldwide have elevated Lp(a) levels, but there is no approved medication to target this risk factor for heart disease.
By joining the OCEAN(a) - PreEvent study, you may contribute to research that aims to better understand heart disease risk and elevated Lp(a).
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Study-related visits with a clinical research study team.
The study drug or placebo is given every few months during the treatment period.
Eligible participants may receive reasonable reimbursements for travel-related expenses.
The study drug or placebo provided at no cost.
See If You May Qualify
Step 1:
This questionnaire will ask for your contact information and a few questions about your medical history to determine your eligibility.
Then, you can select a time for a short phone call with PatientWing. Submitting the questionnaire is voluntary and does not require a commitment to participate in the study.
Step 2:
PatientWing is helping identify potential individuals who may be interested in the OCEAN(a) - PreEvent study.
You will have a short call to answer additional questions about your medical history.
Step 3:
If the PatientWing team has determined you may potentially be eligible for the OCEAN(a) - PreEvent Study, you will speak with the study team at the research site who will review your medical records.
If the study team thinks you are a good fit, they will schedule a screening visit to test your Lp(a) level and see if it’s elevated.
In this initial screening visit, the study team will have you sign an informed consent form prior to testing your Lp(a) level. This consent is voluntary, and you may withdraw it and stop participating at any time.
Step 4:
If the study team confirms your Lp(a) results qualify for the study you will be eligible to move forward with the main screening for the OCEAN(a) - PreEvent study.
At this time, you will be asked to review and sign another informed consent form for the main screening. The study team will provide more information during your conversations with them. No question is a bad question, so please share your concerns with the team.
Step 5:
After you've completed the screening period, the study team will notify you about your eligibility.
If you are enrolled in the study, you should expect the following:
Study participation will last up to 5.5 years.
You will be randomly assigned to receive either the study drug or the placebo every few months over the course of the treatment period.
You will participate in 1 follow-up visit one month following your final dosing visit.
Click Here To Express Interest
Heart disease develops when the arteries that supply blood to the heart become narrowed or blocked, reducing blood flow. This increases the risk of a heart attack or stroke. For many people, heart disease builds quietly over years before any symptoms appear.
Yes. Many people with elevated cardiovascular risk have no symptoms at all.
Heart disease tends to run in families because many of the risk factors that contribute to it are inherited. If a parent or sibling has experienced heart disease, particularly at a younger age, you may be at higher risk.
Your Lp(a) level is inherited. It is determined by your genes, not by what you eat or how much you exercise. Because it is genetic, that means it runs in families. Women, Black adults, Hispanic people, and South Asian individuals are more likely to have elevated Lp(a) levels.
At PatientWing, we’re here to support you at every step of the study. You can email, text, call or fill out the form with any questions. We’re here to help.
